At 50 years old, would you leave an annual comp. of 500K in a pharmaceutical company, for a start up in another industry? The annual comp. in the short term would be a bit lower, but in the long run the risk-reward could be 2X

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If you’re making 500K at Pfizer, I’m guessing you’re probably a VP. Or maybe you have some medical or tech skill that’s highly valued. Wouldn’t getting a promotion or two get you close to that 2x return, with minimal risk? Granted, it’s not like SVP (or whatever your next level is) jobs are abundantly available or easy to get. However, the odds of that seem at least equivalent to a startup being super successful and doubling your comp. All this with the caveat of not knowing anything beyond what you typed. Don’t know anything you’re considering in risk/reward, your financial situation, what you’d be doing and how passionate you are for startup role.

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Thank you for the answer. I appreciate it. You bring a great point to the situation. The job at the startup seems more attractive and aligned with my professional passion. One of the challenges is that I will need to build a network; vs. in my current job, I do have a good network of people. In a big company, significant roles are limited and highly competed. The odds of a big promotion, I would say, are very low.

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Yes I would (as long as you have sufficient savings/not banking on that 500k salary to "make ends meet" in your current situation)

Only if I'm all set financially

I would not because I am risk averse but your tolerance for risk and desire for a challenge may be higher.

I would if financially set. Then hire me!

I would have to be financially set and also really believe in the startup, its vision and leadership. It is an interesting question.

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