How do you combat CNS fatigue? Working out to make muscle gains, not just to stay fit?

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Improve quality of sleep.

You need to improve your sleep, your protein intake, and overall recovery.
You should also have a deload week once every 7 weeks or so.
And probably shouldn’t be overworking your CNS weekly anyways (two heavy days a week split out over the 7 days plus intermediate and a few rest days are imperative).

You can absolutely make muscle gains without sending your CNS to hell

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