Is RNAi a type of gene therapy? What can be considered a gene therapy? Is mRNA a form of gene therapy too?

like
Posting as :
works at
You are currently posting as works at

I don't think these would count as gene therapy because you're not modifying the actual genome or epigenome of your patient with those therapies. It's more like mRNA and RNAi drugs slip into genetic machinery to induce or silence the production of target proteins

likehelpful

Agree. Would call these nucleic acid therapies. You've moved one rung up in the central dogma of biology (DNA>RNA>Protein) for a more durable and targeted therapy but you are not modifying the gene.

like

Gene therapy is generally considered a one time “cure” - RNAi / mRNA are chronic / not curative

likehelpful

Thanks all! Appreciate it.

Wait a sec - it’s not gene therapy because you modify genes?
It’s because you use any nucleic acids for therapy - either DNA (via viral vector or non viral) but also RNA

Please tell me if I’m wrong and source

Wrong. Source: RNA is not a gene.

likefunny

RNAi can be considered a gene therapy, as it modifies the expression of a gene at the post transcription level. Looking through history of gene therapy, you will see that before CRISPR took stage RNA interference was mostly what was implied by gene therapy.

Related Posts

Hey everybody! If anyone is interested in joining a rugby club(mens and womens leagues) let me know. We just kicked off the fall season. It’s a great way to make friends and get a really good workout in.

like

How do you help someone get out of depression?

like

Where to getaway near Austin with toddler, only open to a short few hour drive for 4days? Most places are water parks and I don’t want to expose toddler to germs from water, also not a swimmer.

like

I really struggled with depression during my PhD program. Did anyone else experience this and how did you minimize the damage?

like

Freelancers: What do you do for health insurance?

likehelpful

I just found out we can swim!! Lol 3 months later.... 😹😹😹

funnylike

Rejected by google. Very depressed as was hoping to escape big4 consulting esp with all these h1b crap going on. Unsure of next move- hate going again on the interview treadmill which is depressing

like

Any suggestions for a good gynecologist?

like

When you have a random medical emg, how do you tell your boss/team know you need to take the day?

On the day of?
Take a couple days off? How many?
Update as you go while taking care of what you need to do?

Will this be used against me? Has it ever been used against you?

like

Taking the UBE in 20 days… any advice/thoughts and prayers welcome!

like

Anyone know of a way to get tsa pre while on H1? GEP route is painful for indians

Just started running. Any tips/recommendations you would like to share with this newbie? Thanks 😊

like

Has your investment bank had to start business continuity in Asia due to coronavirus?

like

Thoughts on asking employer if I can WFH during my 2nd and 3rd trimester? My doc said he could write a note to employer noting that it's my request, but I don't want my employer to frown at this.

For context, I no longer work for Deloitte and haven't informed employer that I'm pregnant yet as I'm still in 1st trimester. I have no real medical reason to WFH other than personal preference and added comfortability. Am I being lame or unreasonable?

Now the CDC says teachers don’t need vaccine shots to reopen schools?

like

Any men taking any supplements to improve sperm morphology?

like

I found my first white hair 😱😭 Getting an acne breakout from quarantine was bad enough, now this! Anyone else greying from lockdown stress?

likesmart

I have trouble not interrupting someone when
1.I know what they are taking about and don’t want them to waste their breath going on.
2. Or when I need clarification on something they are talking about.

How have you all dealt with this ADHD tendency?

like

Looking for therapist reccomendations in nyc for anxiety /depression

like

More Posts

How to transition from management consulting to commodity/futures trading (I.e. risk management)? Books to read, general advice, anything is appreciated!

like

NYU applicants: in the extra curricular section did you follow their suggested (org - dates - positions) format? It seems weird thats all they want...no descriptions? Or should I include them anyway?

like

I am having skills of Analytics but not getting job I know Excel and other tools also Power Bi, Google sheets, Google Data Studio, Python, My Sql in learning.

like

Does anyone have any creative suggestions for providing role clarity within teams. We work diligently to maintain job descriptions and communicate team changes broadly, but our employees are still craving some sort of additional reference point of how positions interact with one another. We have Sharepoint and we’re thinking of putting more job info there next to peoples names and titles. Look forward to suggestions!

like

Does anybody else experience those moments during audit where you‘re like, wait do the others also just pretend to know what they are doing and in the end we‘re just a team of scammers?

like

Hi, Could you please brief about IBM Interview process. How many rounds of interview and how long it will take to release offer letter after first technical round?IBM

Domain- SAP with 6 YOE

like

Anyone from Amazon willing chat / possibly give a referral? Thank you in advance!

likehelpful

Is there anyone in here who is retired from the military and now lives and works in S. Korea? I have questions about pros and cons of working as a GS, contractor, or NAF employee (whatever you might be.) Also, are you using an MTF or Tricare Overseas, and how does that work?

like

Opening for CIEC for senior data engineer.

Post Photo

@Palantir, hire me and you'll be redeemed 😂

like

I have joined one MNC company in month of August,

I was hired for a project specific requirement, Unfortunately after holding me for 4 months they told me that the project went on hold. They have created one dummy project code and mapped me to that and they are not releasing me from that account. I am not in project but in Billing.

Please suggest what to do?

YOE - 4

Skills - Java

like

Thoughts about insurtech space? I am looking to at exploring data analytics related innovations as a product manager. Currently in HCM space where recruiting and EdTech is all the buzz. How dull or interesting is insurtech data analytics wise? Specifically, any thoughts about Applied Systems?

like

Hi fishes,
Wanted to know if we have medical insurance and if so the limit and the dependents list.. I'm joining soon and am not sure of this

Thanks

Hi,
My current CTC is 3700000 PA (All fixed). I am getting an offer in singapore 10000 SGD PM. I am not married. Is it good to accept this offer?

like

Hi all! I’m moving to Abu Dhabi next week from Europe.

Any tips ok getting set up in the UAE? Things I should bring?

like

YOE- 4 years
Current CTC -7.5

Offers in hand
Capgemini - 12
Tata technologies. -17
KPMG india - 16.3 + 2 JB

Technology - SAP ABAP

Any advice which one should i consider?


Capgemini KMPG TCS

like

Hi. People Manager here. I've been one for 12 years now and I encourage my team to not be "yes" people. At this time, it feels like my manager wants me and my team to be yes people for her. How do I deal with this? I've never been a yes person and I don't preach this to my reports. I don't know what to do. Help?

Just resigned but I’ve been interviewing for a similar role for years and I’m not getting anywhere. Interviewers would not say it but I think it’s because I didn’t graduate from a US law school though I have NY bar admission. I’m considering a career pivot to contracts management or compliance roles. Anyone have some tips on how to get over the “outside the US” school challenge or how to start moving to a different role?

like

Additional Posts in Life Sciences Consulting

I’m considering a Life Sci Manager position with Accenture. I left another LS firm recently where I was a Consultant. I would love to hear your view on Accenture’s LS practice and which capability?

like

What should be a good salary for IT Lead Analyst role at big pharma ?

like

Hello guys/gals. I’m a newbie in the consulting & LS space, so pardon if my question is a bit remedial to the more experienced fishes. Is “Commercial Operations” synonymous with “Sales?” What exactly does “Commercial Operations” in the LS space entail? T.I.A!

like

Does anybody know what TC is for a BridgeBio Director of BD and Ops?

like

whats the average base salary for a senior consultant at Guidehouse? specifically “life sciences strategy”

like

IQVIA Consulting vs Clearview Healthcare Partners?
...in terms of prestige, exit opportunities, training, work life balance. Also does anyone have any thoughts on the Roivant Sciences?

likesmart

What TC % increase would you jump ship for, assuming you love where you work but are facing a really cool new opportunity?

funny

What LS consulting focus area/niche do you all think will be most in demand, 5 to 7 years from now? And why?

like

Any thoughts on ClearView Health Partners? I’ve come across them a few times at the client or at pitches. Interested to know if good to make a switch from Big4? I realize they are Vault ranked

like

MS degree, 4YOE, currently working at a boutique life science consulting in NYC, ~132k TC, managing 10 people across 3 clients.
Client offered TC ~220k (170k base) with travel comp for a SM job, top 40 biotech by market cap.

Pros - 0 transition (same work/team), wlb, TC, no relocation, have an advocate
Cons - wanted AD but offered SM, less exposure to different work, more personal effort to keep up w industry knowledge and new tools

Worth the jump? Any thoughts/comments are appreciated!

like

thinking about a boomerang back into consulting. 15 years of experience, former T2 and currently at IQVIA. Total comp only ~260K with admittedly strong WLB. What firms should I be looking at for $400K+ TC and some semblance of WLB?

like

Hi all- I’m interested in a position at ZS Associates. Can anyone here speak to the work/life balance there? Any level’s feedback is welcome but I am assuming the position I am interested in is at a manager level. How is their hybrid work environment? Travel expectations? Etc. Thanks so much!

like

What are the emerging fields / capabilities for big pharma?

Currently doing some very traditional stuff and bored.

like

How common/difficult is it to jump from CRO to consulting (entry level roles at ZS, Guidehouse, etc.)?

like

Thoughts on a transition from ZS to LEK? Comp would be in similar. Would like to know how to prepare for interviews differences in culture. Don’t want to waste my time trying and especially theirs.

likehelpful

Anyone do work in cell or gene therapy? Would love to pick your brain. Many thanks in advance!

like