Is there such a thing as durability of a small molecule? Like you take it once a day probably, but how do you measure the robustness of the therapy? I am thinking efficacy may be a slightly different metric. I understand durability of a gene therapy...like how long it should last. But can’t think of a similar metric for small molecule.

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Is there such a thing as durability of a small molecule? Like you take it once a day probably, but how do you measure the robustness of the therapy? I am thinking efficacy may be a slightly different metric. I understand durability of a gene therapy...like how long it should last. But can’t think of a similar metric for small molecule.

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Yes this is an efficacy endpoint known as DoR (duration of response) - most often used in oncology alongside ORR and CR/PR/SD/PD.

If you’re talking preclinical - you’re looking at PK T1/2, tumor inhibition % and duration of PD response.

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Listen to D1. He/she knows their shit.

OP I think you are looking to understand pk/pd

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Durability? So like half life?

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Pkpd would be a related way of measuring this, though it doesn’t necessarily translate to what you’re trying to get at I think.

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Robustness is an awkward word to use here I think. I think you're referring to stability which is related to shelf life or PK/PD which is related to frequency of administration. Both dependent on a lot of factors.

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I saw a clinical trial use "durability of response" as a secondary endpoint a while ago. It was a biologic but I could see it making sense for small molecules

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Durability is more of a long term efficacy question - sure we saw a 30% reduction in primary outcome for 18 months in clinical studies, but is that reduction maintained at the 3 years? 5 years? Etc. Real world evidence has entered the chat

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🙋🏼‍♀️ 🐟, can you please post the salary range for band 7 in @standard chartered and the tech stock like Tableau , Microstrategy and powerBI

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8 months

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How long does it usually take to hear back from a job you applied for? I just applied about a week ago but I’m anxious 🤣. Before I always applied for job in PA and the recruiting process is always quick (hear back/ have final offer within a week). Not sure if it’s the same case for private. TIA!

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7 months

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Hi Fishes,

I need 11 likes to enable DM. Please help 🥺

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5 months

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Fellow fishies, what would you do if you’ve hit a ceiling in your current role and after attempting to transfer was asked to stay and not leave the company. Vacation package is quite good but that’s about it.

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6 months

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How helpful is the FMVA cert to transfer to IB with very limited deals & fin modeling experience from risk consulting?

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2 months

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What do you guys do around office hours? Do you have a formal policy? Next year I' m considering closing my office at noon during the summer, just wondering how to communicate that to people.

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How much salary should I be getting in the market if I have 7 yrs of experience in Learning and Development?

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a month

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I have a salary range in mind for a new role based on online research and target increase from my comp now. But my research shows the data points are for salaries in HCOL areas. Do I need to adjust what I ask for if it’s a remote role and I’m not in HCOL city? Don’t want to overshoot and lose a great opportunity.

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Does anyone have a POC at TikTok regarding gaining access to their self-serve paid Ads platform? Anyone having trouble gaining access to it?

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Visual Storyteller

Can anyone relate?

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Do any of you work from home women have a standing desk and treadmill setup? Saw a post today on LinkedIn and it made me curious. Wondering if it’s really sustainable and if the treadmill makes a lot of noise.

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Is going from outside sales to inside sales a step back in career?

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a month

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Hi guys,

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Currently, I am working on my 3rd project. So, according to my experience & job location, what should I ask the company to pay me according to the market value?

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6 months

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Put a 2-din cheap Chinese touchscreen entertainment system in my car. It is like a mini android tab: works great and looks wonderful. Couldn't be happier!!

8 months

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Senior manager - sometimes it helps when you directly respond to me when I sent you and a manager something for approval or have questions instead of me got relay a message from the manager.

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Hello, I am a fresher with 1.3 years of experience. I had a HR/consultant round today. I was told that my CTC is 9LPA.
The question is, should I join OFSS Bangalore or Pune?
Also, if anyone here can guide me on how I can negotiate the offer, they also told me that variable pay will be 10%, which can increase or decrease based on your and the company's performance. My current CTC is 5LPA.

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Does anyone want to connect and perhaps build a friendship? I’m a 28 year old married female wondering why it’s so hard to make and keep close friendships :(

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Hi Fishes anyone recently got interviewed for Dynamics 365 team in India ? What is the interview process like ?

Hi I have joining tomorrow,I have not yet received the onboarding pass. I actually got my joining preponed. Any advice?Cognizant

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10 months

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How is the culture in p&o vertical of pwc india? Weekend working? Decent hikes? Good managers?PwC India

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What are the best consulting companies to work for in life science consulting? Specifically for supply chain.

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10 months

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I have a strong medical + science background ( physical therapy ) , but looking to transition into healthcare consulting industry. Any tips/advice welcome. EY Deloitte PwC Accenture

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Hello People!
I am interested in knowing about the work culture and growth in CACTUS COMMUNICATION and PREMIER RESEARCH (Bangalore). It would be wonderful if anybody can throw some light on their experience with the organisations.

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Keep hearing that TRINITY is getting too top heavy due to staff departures…any thoughts on if this is accurate or what is causing this trend?

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Anyone ever work at BMS as an employee? Not as a consultant? Pros and cons?

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Interviewing for GT’s Operations Transformation Senior Associate in the Life Sciences division . Can anyone share more on the interview process after the initial screening ? Grant Thornton

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10 months

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For all the ex-consultants out there now in big pharma: have any of you signed up to be an expert/advisor at one of the expert networks (GLG, Guidepoint, Atheneum)? I’m at a big pharma now and wondering if it’s allowed to consult in an expert network as long as I don’t discuss anything confidential or related to my company.

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Can anyone share comp expectations for SM in corp dev at biotech vs. established big pharma?

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What is the worst / most difficult life sciences client to work with? Curious how everyone feels working with the different companies.

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What are the best projects to get on if I want to exit into life science PE/VC? I don’t have an advanced degree so I’m talking about smaller shops

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7 months

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Has anyone ever heard of WNS? A recruiter just reached out about a US based pharma commercial ops role, but I’ve never heard of them. Looks like an Indian conglomerate and seems sus

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Are signing bonuses common when moving to AD/D roles in industry?

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Thinkinf about taking a sales role at Iquiva, what are some of the challenges that im not thinking about?

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Has anyone here successfully exited to pharma after 1-2 YOE? Currently an SA at a small NYC market access firm with a wide range of projects under my belt for big pharma clients. I'm anticipating a promotion to AC perhaps this fall or winter, but I'm at a crossroads where I'm not sure if I want to continue consulting to the actual consultant level. Currently make $100k with a 10% bonus, would I even get a higher salary in industry at this stage? Also might be worth noting I have an MPH. Thanks!

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I’m interested in exiting to product management/marketing roles in industry but I’m finding it to be very limited for people with <5 YOE and no MBA. Mainly still in consulting because you can make close/100k+ with 2-3 yoe. Are there roles that make 100k this early in career in industry or should I wait it out?

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associate at ZS Associates (entry) vs Senior consultant (2nd level) at Guidehouse Choosing between both as an experienced hire. Focused only on life sciences. Any thoughts?

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Anyone work w RegDev?

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Thoughts on TDG? They seem to be growing quite quickly

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Does anyone have insight into the rollout of the ZS DC office? Looking for a LS role in the DC area! Currently working in LS Strategy (think Clearview, Trinity etc)

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