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Conflation of factors but original center of research talent was in New York, New Jersey, Philadelphia, and Wilmington Deleware areas.
J&J, Astrazeneca, Dupont, Rohm & Haas, Wyeth, Merck, BMS, and other companies all originated there and then in most cases remained. The branded and then the generics also located there.
Then there were and have been tax and other financial incentives.
Also availability of staff: NJ has the highest concentration of engineers and scientists in the US. https://www.politifact.com/factchecks/2012/sep/06/choose-new-jersey/new-jersey-leads-world-number-scientists-engineers/