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I think the biggest piece of advice I can give you is to find your internal allies. Every big org has its informal network of people who get things done. Find those folks early, and your job will be so much easier. Also, bring your biotech mindset with you. Big pharma really values and will look for ways up for fresh, agile thinking now more than ever. Your ability to think fast, pivot, and challenge processes will set you apart.
Figure out who the people w/power are. Information flows downhill in bigger companies, so find some sources and keep them confidential. You'll learn about changes coming down the way before your manager lets you know. Knowledge is key.