Is there an “official” way to see when a drug comes off patent? Also if it’s popular and expensive, I assume generics will be available very shortly (days/weeks) after patent expires

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You can check the orange book (drugs) and purple book(biologics) on FDAs website. The patent and exclusivity information is posted there.

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Agree there’s no official way but you can estimate from the FDA Orange Book database

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Generic have to go through a clinical trial as well. They have to be bio-similar. So depending on cost of manufacturing and the market size will determine if generic drug manufacturing companies will manufacture the drug.

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