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I made the transition from public role to Pharma four years ago. It was a rough transition for me but now I love it. Learning the jargon and ways of working were the real difficult part for me. I came into a marketing strategy role because of my expertise in a therapeutic area. The program I was working on was paused and I then needed to scramble to find another role. So the instability and quick changes that come in this industry were a big adjustment.
I transitioned from Academia roughly 6 yrs ago, there is a lot to learn, but I love it. The toxicity level in my experience is lower in pharma. R&D is pretty stable, but depends on your level.