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Between people leaving government and private sector layoffs, jobs are extremely competitive right now. Don't delay starting your job hunt because it could take you months or even longer to find something.
There are a lot of people having to make this transition right now. Private sector job market is looking pretty bleak right now too but pharma and healthcare are doing decent. I don't think you'll struggle to explain your pivot but start applying now while you're still employed. That's always a better way to job hunt
There are a lot of people fleeing from the government, and with tonight's news about the EPA there will be many more. So it's not a great time to be looking for work, as the competition will be pretty rough. But, in a lot of cases people don't have any choice, they need to find a job somewhere.
I would start looking sooner rather than later. The job market is really rough right now. If you can get a referral, those always help.