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Hi, I'm leaving Citi in 2 months.It's hard to make this decision. I have an offer from a small startup.In citi, my previous experience was not considered and was reskilled to different tech which is the reason for change.I don't like to exit citi. As I like the company so much.But considering my current knowledge,I am in the middle of the sea.I am afraid now that the new company's offer would be revoked due to this recession?Or can I take back my resignation in citi before the last working day.Is this wise decision?
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For my pcos ladies on metformin, interesting news article. Be careful out there. The good news I hear is that metformin leaves the body pretty quickly so in 2 days you won't have it in you anymore. https://www.google.com/amp/s/www.forbes.com/sites/victoriaforster/2020/04/05/researchers-warn-that-covid-19-treatment-t
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Has anyone here tried pregmune?
For what reasons are you doing IVF?
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PGT-A is important because it will tell you about viability. It doesn't necessarily gets discarded, they can't unless they get your consent + and your husbands.
Pro
I tested on the two rounds that made it to blastocyst, and am so glad I did. I’m still deeply mourning the two abnormal blasts from my first round. I can’t imagine how much worse it would have been if we had implanted and I had two miscarriages instead.
This process is hard. Be gentle with yourself and give yourself grace. Ultimately whatever you decide will be the right choice for you.
I don’t regret doing it, but you have to have the expectation that it’s not perfect.
I’m in the pro-PGT-A camp, but if you do it, I would just clarify that your lab reports mosaics, and at what threshold. Mosaics absolutely have the potential for self-correction and live birth, and in the past would often just be reported as aneuploid - leading to the disposal of embryos that could’ve resulted in live birth. This has changed a lot in the last several years. True aneuploids are *incredibly* unlikely to be successful (if they are, they were probably actually a mosaic that tested as aneuploid) but some clinics will still transfer them for you. At minimum, results can be useful in understanding your likelihood of success and choosing which to transfer first.
Pro
I did testing and as a 39 year old at the time of egg retrieval I’m super glad I did. The percentage change of having an abnormal embryo are SO high the older you get. I had 21 eggs retrieved. 16 fertilized. 9 blastocysts and 4 euploid and that was considered “great”.
I only want one (I have one already from IUI) and it’s highly likely I won’t use all 4 embryos. I do know my clinic gave me the option for discarded embryos to be used for testing and other ways to advance fertility studies and that made me feel better about the decision. It’s all science in the end.
Having a scientific background, I would not waste the money on a genetic test that has questionable/inconclusive results, no matter how much my fertility doctor pushed it. I would, however, find a new doctor if they kept at me to have the testing done. Especially after I gave my "No" answer to the testing. From what I just read, I would absolutely say it is a cash grab for both the laboratory doing the testing and the doctor. Hell, even genetic testing of a developing fetus in utero is not 100%, and false positives and negatives happen.
My science background is in Biology-forensic (including genetics courses) and microbiology.
From my research, $200 is rather reasonable considering the fees I found were $200-250/embryo sampled and then another $2000 to $7000/embryo for the actual genetic testing. However, if you want to spend the money to make yourself feel better, then that is your right.
I did PGT-A and PGT-M. I don’t regret either. They can tell you the exact reason why the embryos appear as aneuploid or mosaic, it’s up to you and your RE if you transfer them, however I doubt many REs will transfer aneuploids due to their success rate stats.
We’ve done 4 retrievals with PGT-A testing and got 2 euploid and 1 LLM but missing a Y chromosome.
The first transfer didn’t implant and the second resulted in a MMC at 9 weeks. I’m 41 and was aiming to have a kid by 40. If I had more time I might consider not testing, but I wanted to reduce the risk of miscarriage as much as possible so as not to waste as much time, but am not trying to have a kid at any cost.
After getting the LLM results we spoke to a genetic counselor who said there was a 40% chance of implantation and a 2% chance that the chromosome issue would actually manifest. Even with PGT-A testing they still recommended pre-natal genetic tests because they acknowledge the results are not 100%. The number of cell they sample is the smallest size possible to be statistically significant.
It is a very personal decision, but probably a good precursor for how so many things are out of your hands when it comes to having a kid. There’s a reason they say being a parent is like your heart running around outside your body.
I’m deciding what to do myself. But the way the doctor explained it was that there’s a 50% chance even with genetic testing. It doesn’t guarantee success , that there’s still a million things that can go wrong. He said genetic testing tells you which have a 50% chance and which have a 0% chance.
OP specified PGTA, which really just counts chromosomes
I did PGT-A testing. I froze embryos following a cancer diagnosis so I wanted to collect as much info as possible about my embryos’ health (understanding the data isn’t perfect). This way I can also avoid implanting an embryo that may likely end in a miscarriage.
I also had a cancer diagnosis and had to freeze embryos… uterine cancer :( currently pursuing fertility sparing measures to try and clear it before transfer
I would do it! Totally worth it to minimize tranfers
I did PGT-M testing which includes PGT-A. I am very glad that we did it because the results were extremely helpful.
I did PGT-A 4 separate times, then like you, I did my research. I then found another doctor who thankfully had a lot of fertility research experience and was also skeptical of all the PGT testing being pushed in the industry. They are essentially doing a biopsy on your delicate embryo...shipping a sample...freezing the rest and eventually thawing your embryo. I decided PGT was too much handling and potential to mishandle your delicate embryos. Not every clinic or lab has the expertise to do this right.
This time we decided NOT to do PGT tests... and we finally got pregnant. Today I have a healthy beautiful baby that is 8-months.
Please read this article/research: "PGT-A Houston we have a problem" https://pmc.ncbi.nlm.nih.gov/articles/PMC10504172/
This is interesting. I had to do PGTM in my case due to not wanting to pass on a condition, but if not for that, I think I still would have chosen PGTA because I had a niece born with a trisomy and it’s definitely not easy watching what they had to go through. If for neither of those, I would have passed on the testing.