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Unusual to see someone ask about staying in Mission Valley or La Mesa as they are not exactly similar areas. I would prefer mission valley ovee la mesa. Mission valley itself it’s just kind of a typical corporate area with a really nice mall and some upscale chain restaurants but is also very close to La Jolla in downtown. If I remember correctly most of the hotels are a little bit older in that area but there is a brand new Springhill suites that was nice for what it was. Better hotels in San Diego would be La Jolla or downtown.