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Most likely money. I have to think that some industry (probably alcohol) is lobbying hard to keep marijuana illegal. That and puritanical attitudes toward anything related to cannabis. I think our best hope of it getting reclassified is someone telling Trump he could make a fortune off his own branded strain.
That's a good question. A lot of political figures are still stuck in the era of Reefer Madness films. What will probably change it is the success of weed related businesses and the lobbying power that will come from that. It's already having an effect at the state level in some places.