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I have not done this before, but would say you could still make it the landscape orientation just do not exceed that 42x42 guideline. I think they have to say something so nothing gets too out of hand maybe. For actual measurements play around with what looks the best in a preview before making choices.
I like to keep my posters manageable so I go with 36 x 42 its big enough to see and fits most conference guidelines
It all depends on what topic youre doing my work is better in portrait as it usually has a big vertical diagram