Does pharma pay significantly more than a standard agency?

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Yes but you will never be hired at a creative shop again

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If you have deep industry experience? Absolutely

I always wondered this - I've always heard it pays more, but how much more? Like is a strategy director in pharma making 50k more with similar years of experience?

Depends on what you mean by significant and what your level is. Titles also mean different things. Standard agency is CW - SCW - ACD - CD, whereas pharma is CW - SCW- Copy Sup - Group Copy Sup - ACD - CD. Copy sup and GCS end up acting more like an ACD at a traditional agency, and an ACD ends up acting more like a CD.

My progress (note these are midwestern prices) was as follows:
CW - 70k
SCW - 90k
Copy Sup - 115k

Then I jumped over to a traditional agency and I'm making 135 as an ACD. If I were a Group Copy Sup, I'd be making around the same, whereas pharma ACD makes about 175-190 but has more work than I do. At the very highest levels the pay isn't that different from what I understand.

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