What is the best way to approach a situation where you have worked for a CRO on a FSP, fully-embedded program for over 10 years and have always had amazing bosses, until about two years ago when i was transitioned to this newish manager, and things went south and are not going to get better anytime soon? Do i contact HR of my company? Or rather just escalate slightly to my managers boss? Anyone who can help, im grateful.

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I would probably go to HR. You could go to your managers boss but your manager could retaliate so it is always best to loop in HR so you are covered. I would probably start looking for a new job as well in case things get worse.

Do you have colleagues in the same situation? Maybe team up with them to talk to your new boss or HR. Or if youhave a good relationship with your previous boss, ask them for advice. Or you could try to find an excuse to get into another team, like you would like to learn a new therapeutic area or early phase or late phase or biotech or whatever.

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