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I’m sorry to hear about this; I have. NCI-Sponsored trials can be a great idea. They definitely use treatments that are new and/or new treatments in conjunction with one that is already FDA approved. I hope it was caught early, sending positive vibes.
Thank you for your concern :) And for the information. This makes me happy. He was caught in Stage 2 which is safe enough for a trial like this.
I have worked on them at a previous company! I’d say go for it! Pediatric oncology in the US at least is 70% treated on some clinical trials protocol. The data on ped onc is sparse in comparison to adults. The treatments and the reviews at the NCI in pediatrics are the latest and greatest. If my kid had the opportunity in the same situation, I’d go for it!
Also, the NCI enters partnerships with big drug companies who don’t want to spend the money on researching for kids bc it’s too rare. And the research consortiums that handle these studies are EXTREMELY specialized. I have worked on general adult oncology trials, but NCI pediatric trials and the consortiums of investigators they work with, are next level. Also, i worked on 20+ of these studies on the early phase level, and I’ve never seen one where the drug wasn’t first approved for use in adults. Ethically, it’s just very unlikely to ever have a first in human in kids. I don’t think I’ve even heard of it unless you’re talking super super rare disorders like SCIDs
No, but I coordinate enrollment and manage pediatric patients on these studies. Many of our oncology studies at my site are through the Children's Oncology Group, and almost all of our patients who are eligible go on trial. Even the ones who aren't eligible for the trials usually get treated according to an older protocol.