For those of you who had miscarriages after IVF, was there an underlying cause? Did you do genetic testing of your embryos? Did you do frozen or fresh transfer? Are there any ways to minimise chances of miscarriage during ivf?

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My wife had a miscarriage after about 6 weeks with a fresh transfer. Genetic testing is pending.

We had a failed IUI and after 2 rounds of IVF we only have one genetically sound embryo frozen. Losing hope.

Did you do genetic testing?

I had 2 miscarriages and 3 chemicals. Now most likely going through a 4th chemical. No answers.

I’m so sorry AP1. Not knowing is the worst.

I miscarried at 14 weeks with a PGT-normal (confirmed normal/no karyotype issues by fetal tissue test). This was following a VERY conservative first trimester of pregnancy (due to fear of miscarriage!). They ran a few blood tests and didn’t see anything off, and basically told me it was just really bad luck, and ‘these things happen’. After a brutal and devastating IVF journey… bad luck is not a sufficient or satisfying diagnosis. Next time, if we get a next time, I’m going to ask for an antibiotic before the transfer, more regular blood pressure and hormone level screenings, and absolutely will work with a high-risk OB.

PM1 - I was just very cautious about diet (not a drop of alcohol or caffeine, rigorously tracked nutrients); exercise (used to do a lot of Pilates and HIIT, and moved to only walking and yoga); got 8 hours of sleep and took time off to manage stress; made sure to thoroughly wash food before eating; avoided gardening; etc. Not all of these are even correlated with miscarriage reduction but I really wanted to not feel like I could blame myself if something went wrong. And, to be fair, I don’t - I really did everything the old school textbook way.

Was weaned off meds in week 11 and as of week 13 all hormones looked great (OB told me I was a ‘picture-perfect pregnancy’ after a 14 week anatomy scan, right before there was no heartbeat 2 days later). We are also dealing with unexplained infertility and a ‘bad luck’ IVF cycle, so we don’t have any other diagnoses to work off of.

I know we may not ever get an answer and I’ve made peace with the unknowns about that pregnancy and the loss of that baby, but I am not willing to put myself, my body, or my relationship through that again if there is anything we can learn or do differently next time. So, EY2, I am willing to explore speculative medicine, and that is an active choice I am making (while weighing all research and medical guidance carefully).

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