Has anyone ever switched pharmacies for their SSRI and their new one started working less effectively? Same active ingredient but different pill (color, shape, etc), so I think a different generic form.

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Definitely talk to your doctor and ask them to specify when they write the script that it can’t be subbed out for a different generic. It could be a non-active ingredient that is hitting you differently. This hasn’t happened to me with SSRI’s but it did with birth control and caused some weird side effects (inc me skipping a period which you can imagine was very scary). I started reading up on it (I don’t have the article handy) but apparently generic meds can have somewhere like 30% of a difference in non-active ingredients from the brand name drug so it’s highly likely there’s an inactive ingredient working against you.

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I used pill pack and they switch manufacturers all the time. Never noticed anything like that.

I have noticed differences in efficacy for different genetics - could be in my head, but still…

Maybe talk to your doctor or even the pharmacist about this and see what they say?

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